Zheng Meizhen Lab 郑梅珍实验室

PUBLICATIONS

Dr. Zheng has published over 20 peer-reviewed journal articles, including significant contributions as first or corresponding author in prestigious journals such as Nature, Science Advances, and The EMBO Journal. Since joining SUSTech, her publication record includes 7 papers where I served as the last corresponding author and 3 co-authored papers, along with 4 first-author publications and 10 co-authored articles before joining SUSTech.

Corresponding author

  1. Tian, Simon Zhongyuan#,*; Yang, Yang#; Ning, Duo#; Yu, Ting#; Gao, Tong; Deng, Yuqing; Fang, Ke; Xu, Yewen; Jing, Kai; Huang, Guangyu; Chen, Gengzhan; Yin, Pengfei; Li, Yiming; Zeng, Fuxing*; Tian, Ruilin*; Zheng, Meizhen*. Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulation. The EMBO Journal, 2025, 1–44.

  2. Tian, Simon Zhongyuan#,*; Yang, Yang#; Ning, Duo#; Fang, Ke#; Jing, Kai; Huang, Guangyu; Xu, Yewen; Yin, Pengfei; Huang, Haibo; Chen, Gengzhan; Deng, Yuqing; Zhang, Shaohong; Zhang, Zhimin; Chen, Zhenxia; Gao, Tong; Chen, Wei; Li, Guoliang; Tian, Ruilin; Ruan, Yijun*; Li, Yiming*; Zheng, Meizhen*. 3D chromatin structures associated with ncRNA roX2 for hyperactivation and coactivation across the entire X chromosome. Science Advances, 2024, 10(30): eado5716.

  3. Yang, Yang; Chen, Gengzhan; Gao, Tong; Ning, Duo; Deng, Yuqing; Tian, Simon Zhongyuan*; Zheng, Meizhen*. Tn5-Labeled DNA-FISH: An Optimized Probe Preparation Method for Probing Genome Architecture. International Journal of Molecular Sciences, 2025, 26(5): 2224.

  4. Jing, Kai; Xu, Yewen; Yang, Yang; Yin, Pengfei; Ning, Duo; Huang, Guangyu; Deng, Yuqing; Chen, Gengzhan; Li, Guoliang; Tian, Simon Zhongyuan*; Zheng, Meizhen*. ScSmOP: a universal computational pipeline for single-cell single-molecule multiomics data analysis. Briefings in Bioinformatics, 2023, 24(6): bbad343.

  5. Tian, Simon Zhongyuan*; Li, Guoliang; Ning, Duo; Jing, Kai; Xu, Yewen; Yang, Yang; Fullwood, Melissa J; Yin, Pengfei; Huang, Guangyu; Plewczynski, Dariusz; Zhai, Jixian; Dai, Ziwei; Chen, Wei; Zheng, Meizhen*. MCIBox: a toolkit for single-molecule multi-way chromatin interaction visualization and micro-domains identification. Briefings in Bioinformatics, 2022, 23(6): bbac380.

First author

  1. Zheng, Meizhen; Tian, Simon Zhongyuan; Capurso, Daniel; Kim, Minji; Maurya, Rahul; Lee, Byoungkoo; Piecuch, Emaly; Gong, Liang; Zhu, Jacqueline Jufen; Li, Zhihui; Wong, Chee Hong; Ngan, Chew Yee; Wang, Ping; Ruan, Xiaoan; Wei, Chia-Lin; Ruan, Yijun*. Multiplex chromatin interactions with single-molecule precision. Nature, 2019, 566(7745): 558-562.

  2. Zheng, Meizhen; Zheng, L-M; Zeng, Yi-Xin*. SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase. Journal of Cancer Research and Clinical Oncology, 2008, 134: 453-462.

  3. Zheng, Meizhen; Qin, Hai-De; Yu, Xing-Juan; Zhang, Ru-Hua; Chen, Li-Zhen; Feng, Qi-Sheng; Zeng, Yi-Xin*. Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population. Journal of Translational Medicine, 2007, 5: 7.

  4. Zheng, Meizhen; Jiang, Jianwei*. Progress in unmethylated immunostimulatory oligodeoxynucletides. Progress in Biochemistry and Biophysics, 2003, 30(2): 190-193.

Co-author

  1. Chen, Rui; Shi, Xinyao; Yao, Xiangrui; Gao, Tong; Huang, Guangyu; Ning, Duo; Cao, Zemin; Xu, Youxin; Liang, Weizheng; Tian, Simon Zhongyuan; Zhu, Qionghua; Fang, Liang; Zheng, Meizhen; Hu, Yuhui; Cui, Huanhuan*; Chen, Wei*. Specific multivalent molecules boost CRISPR-mediated transcriptional activation. Nature Communications, 2024, 15(1): 7222.

  2. Li, Zhuowen#; Long, Yanping#; Yu, Yiming; Zhang, Fei; Zhang, Hong; Liu, Zhijian; Jia, Jinbu; Mo, Weipeng; Tian, Simon Zhongyuan; Zheng, Meizhen; Zhai, Jixian*. Pore-C simultaneously captures genome-wide multi-way chromatin interaction and associated DNA methylation status in Arabidopsis. Plant Biotechnology Journal, 2022, 20(6): 1009.

  3. Chen, Tao#; Lin, Yu-Xin#; Zha, Yan#; Sun, Ying; Tian, Jinxiu; Yang, Zhiying; Lin, Shan-Wen; Yu, Fuxun; Chen, Zi-Sheng; Kuang, Bo-Hua; Lei, Jin-Ju; Nie, Ying-Jie; Xu, Yonghao; Tian, Dong-Bo; Li, Ying-Zi; Yang, Bin; Xu, Qiang; Yang, Li; Zhong, Nanshan; Zheng, Meizhen; Li, Yimin; Zhao, Jincun; Zhang, Xiang-Yan; Feng, Lin*. A low-producing haplotype of interleukin-6 disrupting CTCF binding is protective against severe COVID-19. MBio, 2021, 12(5).

  4. Wang, Ping#; Tang, Zhonghui#; Lee, Byoungkoo; Zhu, Jacqueline Jufen; Cai, Liuyang; Szalaj, Przemyslaw; Tian, Simon Zhongyuan; Zheng, Meizhen; Plewczynski, Dariusz; Ruan, Xiaoan; Liu, Edison T; Wei, Chia-Lin; Ruan, Yijun*. Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia. Genome Biology, 2020, 21. Jan-21.

  5. Kim, Minji; Zheng, Meizhen; Tian, Simon Zhongyuan; Lee, Byoungkoo; Chuang, Jeffrey H; Ruan, Yijun*. MIA-Sig: multiplex chromatin interaction analysis by signal processing and statistical algorithms. Genome Biology, 2019, 20: Jan-13. Impact factor: 14.3

  6. Li, Xingwang#; Luo, Oscar Junhong#; Wang, Ping; Zheng, Meizhen; Wang, Danjuan; Piecuch, Emaly; Zhu, Jacqueline Jufen; Tian, Simon Zhongyuan; Tang, Zhonghui; Li, Guoliang; Ruan, Yijun*. Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions. Nature Protocols, 2017, 12(5): 899-915.

  7. Dekker, Job; Belmont, Andrew S; Guttman, Mitchell; Leshyk, Victor O; Lis, John T; Lomvardas, Stavros; Mirny, Leonid A; O’Shea, Clodagh C; Park, Peter J; Ren, Bing; Politz, Joan C Ritland; Shendure, Jay; Zhong, Sheng; 4D Nucleome Network. The 4D nucleome project. Nature, 2017, 549(7671): 219-226. * Zheng, Meizhen is a member of the 4D Nucleome Network*

  8. Tang, Zhonghui#; Luo, Oscar Junhong#; Li, Xingwang#; Zheng, Meizhen; Zhu, Jacqueline Jufen; Szalaj, Przemyslaw; Trzaskoma, Pawel; Magalska, Adriana; Wlodarczyk, Jakub; Ruszczycki, Blazej; Michalski, Paul; Piecuch, Emaly; Wang, Ping; Wang, Danjuan; Tian, Simon Zhongyuan; Penrad-Mobayed, May; Sachs, Laurent M; Ruan, Xiaoan; Wei, Chia-Lin; Liu, Edison T; Wilczynski, Grzegorz M; Plewczynski, Dariusz; Li, Guoliang; Ruan, Yijun*. CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription. Cell, 2015, 163(7): 1611-1627.

  9. Li, Guoliang#; Ruan, Xiaoan#; Auerbach, Raymond K#; Sandhu, Kuljeet Singh#; Zheng, Meizhen; Wang, Ping; Poh, Huay Mei; Goh, Yufen; Lim, Joanne; Zhang, Jingyao; Sim, Hui Shan; Peh, Su Qin; Mulawadi, Fabianus Hendriyan; Ong, Chin Thing; Orlov, Yuriy L; Hong, Shuzhen; Zhang, Zhizhuo; Landt, Steve; Raha, Debasish; Euskirchen, Ghia; Wei, Chia-Lin; Ge, Weihong; Wang, Huaien; Davis, Carrie; Fisher-Aylor, Katherine I; Mortazavi, Ali; Gerstein, Mark; Gingeras, Thomas; Wold, Barbara; Sun, Yi; Fullwood, Melissa J; Cheung, Edwin; Liu, Edison; Sung, Wing-Kin; Snyder, Michael*; Ruan, Yijun*. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell, 2012, 148(1): 84-98.

  10. ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 2012, 489(7414): 57. Zheng, Meizhen is a member of the ENCODE Project Consortium

  11. Zeng, Huilan*; Han, Xinai; Gu, Chen; Jiang, Jianwei; Zheng, Meizhen; Yan, Yuxia; Zeng, Yaoying; Di, Jingfang. Delivery and immunologic efficacy of CpG ODN targeting B lymphocytes of umbilical cord blood by CD40 ligand-receptor-mediated carrier. Chinese Journal of Tissue Engineering Research, 2009: 974-978.

  12. Zeng, Huilan*; Zhu, Kanger; Jiang, Jianwei; Gu, Huaimin; Cai, Jiye; Cheng, Longqiu; Yang, Zhigang; Zheng, Meizhen. The prevention of acute graft versus host disease by Rhodamine 123-mediated photodynamic therapy. Chinese Journal of Pathophysiology, 2000.

  13. Jiang, Jianwei*; Zheng, Meizhen; Zeng, Huilan; Zeng, Yaoying; Di, Jingfang; Yan, Yuxia; Wu, Meiyu. Preparation of CD40L-PLL-CpG ODN conjugated complex and its targeting B lymphocytes. Chinese Journal of Pathophysiology, 2005.

GRANTS AND CONTRACT

Since 2019, at the Southern University of Science and Technology (SUSTech), Dr. Zheng has secured a total of 8 grants, and approximately ¥27.34 million in total, of which she direct ¥7.54 million, allocated as follows:

External Sources

  1. Epitranscriptome and RNA Macromolecular Interaction Screening Technology. Ministry of Science and Technology, National Key R&D Program (Frontier Biotechnology Special Project); 2022.11–2027.10; PI; Total Funding: ¥20,000,000; Personal Allocation: ¥4,500,000.

  2. Epitranscriptome and RNA Macromolecular Interaction Screening Technology—2024 National and Provincial Matching Fund. Shenzhen Municipal Science and Technology Innovation Committee; 2023.12–2027.10; PI; Total Funding: ¥540,000; Personal Allocation: ¥540,000.

  3. Epitranscriptome and RNA Macromolecular Interaction Screening Technology—2025 National and Provincial Matching Fund. Shenzhen Municipal Science and Technology Innovation Committee; 2024.12–2027.10; PI; Total Funding: ¥121,500; Personal Allocation: ¥121,500.

  4. Development of a Novel RNA-Mediated Genome-Wide Chromatin DNA Long-range Interaction Technology. National Natural Science Foundation of China (NSFC) (General Program).

  5. Study on Chromatin Microdomains as Novel Diagnostic and Therapeutic Targets for Tumors. Shenzhen Municipal Science and Technology Innovation Committee (General Project); 2022.10–2025.10; PI; Total Funding: ¥300,000; Personal Allocation: ¥300,000.

  6. Analysis of EBV–Host Immune Interactions Based on Single-Molecule 3D Genomics Technology. Guangdong Provincial Natural Science Foundation (General Project); 2023.01–2025.12; PI; Total Funding: ¥100,000; Personal Allocation: ¥100,000.

  7. Development of Single Cell and Single Molecule Technologies for Multi-Omics Analysis of 3D Epigenomes. National Natural Science Foundation of China (NSFC) - Foreign Scholar Research Fund; 2023.01–2025.12; Co-PI; Total Funding: ¥3,700,000; Personal Allocation: ¥400,000.

  8. Study on the Mechanisms of Genome Structure Analysis and Genomic Streamlining Key Technologies. Shenzhen Municipal Science and Technology Innovation Committee (Key Project of Basic Research); 2023.01–2025.12; Co-PI; Total Funding: ¥2,000,000; Personal Allocation: ¥1,000,000.

University Sources

  1. Start-up Fund, Southern University of Science and Technology; 2021–Present; PI; Total Funding: ¥8,000,000; Personal Allocation: ¥8,000,000.